Bouillot P, Babak V, Dellacherie E
Laboratoire de Chimie Physique Macromoleculaire, ENSIC, Nancy, France.
Pharm Res. 1999 Jan;16(1):148-54. doi: 10.1023/a:1018895417915.
The objective of this work is to prepare microspheres by the emulsion-solvent evaporation process using MPOE-PLA copolymers as the matrix material and/or the surfactant. This preparation was studied in order to avoid the use of PVA as the surfactant in the process.
Two series of MPOE-PLA copolymers were synthesised. The first, with a long and constant length PLA chain (45,000 g.mol(-1), was used as the matrix material, the second, with short PLA chains (< or = 2.200 g.mol(-1)), and different HLB as the surfactant. Microspheres were prepared by the "simple" and "double" emulsion methods. The steric stabilization effect of the copolymers was investigated using confocal microscopy and X-ray photoelectron spectroscopy (XPS).
Confocal microscopy and XPS analysis showed that the microspheres prepared using MPOE5K-PLA0.5K as the surfactant and MPOE-PLA45K copolymers as the matrix material had an MPOE coating present at the microsphere surface. This hydrophilic layer ensures steric stabilization of the particles.
MPOE-PLA copolymers can be used for the preparation of particles instead of PVA and their use can be extended whenever a biocompatible and bioeliminable surfactant is required for biological or medical applications.
本研究旨在以MPOE-PLA共聚物作为基质材料和/或表面活性剂，通过乳液-溶剂蒸发法制备微球。进行该制备研究是为了避免在该过程中使用聚乙烯醇（PVA）作为表面活性剂。
合成了两个系列的MPOE-PLA共聚物。第一个系列具有长且恒定长度的PLA链（45,000 g·mol⁻¹），用作基质材料；第二个系列具有短PLA链（≤2,200 g·mol⁻¹），且具有不同的亲水亲油平衡值（HLB），用作表面活性剂。通过“简单”和“双重”乳液法制备微球。使用共聚焦显微镜和X射线光电子能谱（XPS）研究共聚物的空间稳定作用。
共聚焦显微镜和XPS分析表明，以MPOE5K-PLA0.5K作为表面活性剂、MPOE-PLA45K共聚物作为基质材料制备的微球，其表面存在MPOE涂层。该亲水层确保了颗粒的空间稳定性。
MPOE-PLA共聚物可用于替代PVA制备颗粒，并且只要生物或医学应用需要生物相容性和可生物降解的表面活性剂，其应用就可以扩展。
