Wang C H, Sengothi K, Lee T
Department of Chemical Engineering and Department of Surgery, National University of Singapore, 10 Kent Ridge Crescent, Singapore - 119260.
J Pharm Sci. 1999 Feb;88(2):215-20. doi: 10.1021/js9803407.
The release of human immunoglobulin G (IgG) using ethylene-vinyl acetate copolymer (EVAc) as a polymer carrier was studied by fabricating them into two commercially available dosage forms: slab and microsphere. A first-order flux decay model and two hierarchical models concerned with the mass transfer coefficient on the slab surface were used to describe the mechanism of release kinetics and the results compared. These models gave insight to some of the important physical parameters of drug release such as the diffusion coefficient, time constant of release, and initial flux. It was found that the release mechanism varies with time, and hence no single model can be used to predict the release profile for the entire period of study. A controlled release study by matrix coating was also done. The results obtained were utilized to examine the suitability of a particular dosage form (matrix geometry) of IgG for clinical applications. The release data compared with the standard methods of IgG therapy proves localized drug delivery to be a major boon for immunodeficient patients.
通过将人免疫球蛋白G（IgG）与乙烯-醋酸乙烯酯共聚物（EVAc）制成两种市售剂型：平板和微球，研究了以EVAc为聚合物载体释放IgG的情况。采用一阶通量衰减模型和两个与平板表面传质系数有关的层次模型来描述释放动力学机制，并对结果进行比较。这些模型揭示了药物释放的一些重要物理参数，如扩散系数、释放时间常数和初始通量。结果发现，释放机制随时间变化，因此在整个研究期间没有单一模型可用于预测释放曲线。还进行了基质包衣控释研究。所得结果用于检验IgG特定剂型（基质几何形状）在临床应用中的适用性。与IgG治疗标准方法相比的释放数据证明，局部药物递送对免疫缺陷患者是一大福音。
