Pineda D A, Sánchez J L
Universidad de Antioquia, Colombia.
Rev Neurol. 1998 Dec;27(160):932-9.
To determine the reliability of a clinical quantitative instrument for assessing the symptoms of Defined Idiopathic Parkinson Disease (DIPD).
From 148 patients with parkinsonism syndrome, the best 62 EPID cases, according to Calne et al (1992), and Larsen et al (1994) criteria--37 males and 25 females--were selected.
The age mean was 68.4 (7.4) year-old, the age of onset was 64 (7.2) years, the time of evolution was 4.3 (2.9) years. 98.4% of the sample was in 1 to 3 Hoehn and Yahr clinical state. Right parkinsonism score (RPS) was 8.2 (4.2), and left (LPS) was 6.7 (4.8). Significant differences between right and left tremor, rigidity and dyskinesia scores were found (ji-squared, p < 0.05). Total parkinsonism score (TPS) was 14 (6.9). Several significant and high correlated coefficients were found between most of the scale's components and Hoehn and Yahr clinical state, TPS, and time of evolution (r > 0.40, p < 0.0001). Total 21 items scale Cronbach's alpha coefficient was 0.92. A stepwise multiple regression model showed that rigidity, postural reflex disorder, and micrography were able to predict the Hoehn and Yahr clinical state (81.4%, p < 0.0001). A principal component analysis showed that akinesia explained more than 59% of the instrument variance, while micrography only explained 0.57% of the variance (100 time lesser).
A reliability structure of the instrument was demonstrated for assessing parkinsonism symptoms in DIPD subjects.
确定一种用于评估明确特发性帕金森病（DIPD）症状的临床定量工具的可靠性。
从148例帕金森综合征患者中，根据卡尔恩等人（1992年）以及拉森等人（1994年）的标准，挑选出最佳的62例欧洲帕金森病联合会（EPID）病例，其中男性37例，女性25例。
平均年龄为68.4（7.4）岁，发病年龄为64（7.2）岁，病程为4.3（2.9）年。98.4%的样本处于Hoehn和Yahr临床分级的1至3级。右侧帕金森评分（RPS）为8.2（4.2），左侧（LPS）为6.7（4.8）。右侧和左侧震颤、肌强直及运动障碍评分之间存在显著差异（卡方检验，p<0.05）。帕金森病总评分（TPS）为14（6.9）。在该量表的大多数分量表与Hoehn和Yahr临床分级、TPS以及病程之间发现了几个显著且高度相关的系数（r>0.40，p<0.0001）。21项总量表的Cronbach's alpha系数为0.92。逐步多元回归模型显示，肌强直、姿势反射障碍和小写症能够预测Hoehn和Yahr临床分级（81.4%，p<0.0001）。主成分分析表明，运动不能解释了该工具方差的59%以上，而小写症仅解释了0.57%的方差（少100倍）。
已证明该工具在评估DIPD患者帕金森病症状方面具有可靠的结构。
