Vázquez-López M E, Pego R, Somoza C, García-Plata C, Rodríguez-De la Riva P, Morales-Redondo R
Servicio de Pediatría, Hospital Xeral-Calde, Lugo, España.
Rev Neurol. 1998 Dec;27(160):986-7.
Meningitis due to Salmonella is an unusual sign of salmonellosis. Usually Salmonella causes clinical disorders of the digestive tract, but on occasions, especially in babies, may cause focalized infections such as meningitis. Although meningitis due to Salmonella is unusual, it should be remembered because of its gravity, since it has a high morbimortality. It mainly affects neonatal babies and those under 4 months of age. It usually precedes or is accompanied by gastroenteritis and has a rapid clinical course.
We present the case of a neonatal baby girl, 17 days old, who was very irritable, had liquid or semi-liquid faeces and high fever of unknown origin with poor response to antipyretic drugs. On lumbar puncture a cloudy liquid, compatible with bacterial meningitis was obtained. Treatment was therefore started immediately with intravenous ampicillin and cefotaxima. CSF culture grew Salmonella which was resistant to ampicillin but sensitive to cefotaxima. Antibiotic treatment was given for 21 days. There was excellent clinical recovery. After eight months of follow-up no sequelae have been seen and her development, both psychomotor, in height and in weight is normal for her age.
Meningitis due to Salmonella is an unusual condition. Immediate, suitable treatment is essential to obtain satisfactory recovery.
沙门氏菌引起的脑膜炎是沙门氏菌病的一种罕见表现。通常沙门氏菌会引发消化道的临床病症,但偶尔,尤其是在婴儿中,可能会导致局部感染,如脑膜炎。尽管沙门氏菌引起的脑膜炎并不常见,但因其严重性(具有高病死率)仍应予以关注。它主要影响新生儿及4个月以下的婴儿。通常在肠胃炎之前发生或与之伴随,且临床病程进展迅速。
我们报告一例17天大的新生儿女婴病例,该婴儿烦躁不安,有液体或半液体粪便,不明原因高热,对退烧药反应不佳。腰椎穿刺获取的浑浊液体与细菌性脑膜炎相符。因此立即开始静脉注射氨苄西林和头孢噻肟进行治疗。脑脊液培养出对氨苄西林耐药但对头孢噻肟敏感的沙门氏菌。抗生素治疗持续了21天。临床恢复情况良好。经过8个月的随访,未见后遗症,其精神运动、身高和体重发育与其年龄相符。
沙门氏菌引起的脑膜炎是一种罕见病症。立即进行适当治疗对于获得满意的康复至关重要。