Prim Espada M P, De Diego Sastre J I, Hardisson Hernáez D, Gavilán Bouzas J
Servicio de ORL, Hospital Universitario La Paz, Universidad Autónoma de Madrid.
Acta Otorrinolaringol Esp. 1998 Nov-Dec;49(8):637-9.
The influence of the extracapsular spread (ECS) of metastatic cervical lymph nodes in patients with laryngeal cancer is discussed. The study included 119 patients who underwent surgery between 1984 and 1992 for squamous cell carcinoma of the larynx and lymph node metastasis confirmed by histology. Results were studied from two main aspects: survival and cervical recurrence. The 3-year survival rate was 73.4% in patients without ECS and 28.9% in patients with ECS (p < 0.001). The 3-year local recurrence rate differed significantly: 23.5% in patients without ECS and 58.3% in patients with ECS (p < 0.001). These results showed that ECS had an unfavorable prognostic significance for lymph node metastasis of laryngeal cancer.
讨论了喉癌患者转移性颈部淋巴结的包膜外扩散（ECS）的影响。该研究纳入了119例在1984年至1992年间接受手术治疗的喉鳞状细胞癌患者，且经组织学证实有淋巴结转移。从生存和颈部复发两个主要方面对结果进行了研究。无ECS的患者3年生存率为73.4%，有ECS的患者为28.9%（p<0.001）。3年局部复发率有显著差异：无ECS的患者为23.5%，有ECS的患者为58.3%（p<0.001）。这些结果表明，ECS对喉癌淋巴结转移具有不良的预后意义。
