Makarov I A, Polunin G S, Kurenkov V V, Smirennaia E V
Vestn Oftalmol. 1998 Nov-Dec;114(6):19-22.
Effects of corticosteroid and nonsteroid antiinflammatory drugs on corneal transparency after photorefraction keratectomy (PFK) in myopia are studied. Corneal transparency was assessed by computer analytical system for the anterior segment of the eye, designed by the authors. Corticosteroids (0.1% dexamethasone solution) more effectively control bacterial contamination of the cornea in high myopia than nonsteroids (0.1% sodium diclofenac solution). A significant improvement of optic density of the cornea was observed 2 weeks after PFK when corticosteroids were discontinued. On the other hand, replacement of diclofenac with dexamethasone 2 weeks after PFK did not result in decrease of optic density of corneal image. Apparently, corticosteroids contribute to decrease of bacterial contamination of the cornea during the very first days after PFK. In myopia of up to -6.0 diopters, the densitometric parameters were virtually the same in the patients treated with nonsteroids and corticosteroids.
研究了皮质类固醇和非甾体抗炎药对近视患者准分子激光角膜切削术（PFK）后角膜透明度的影响。角膜透明度通过作者设计的用于眼前节的计算机分析系统进行评估。皮质类固醇（0.1%地塞米松溶液）在高度近视中比非甾体类药物（0.1%双氯芬酸钠溶液）更有效地控制角膜的细菌污染。在停止使用皮质类固醇后，PFK术后2周观察到角膜光学密度有显著改善。另一方面，PFK术后2周用 dexamethasone 替代 diclofenac 并未导致角膜图像光学密度降低。显然，皮质类固醇在PFK术后的最初几天有助于减少角膜的细菌污染。在高达 -6.0 屈光度的近视患者中，使用非甾体类药物和皮质类固醇治疗的患者的密度测量参数实际上是相同的。
