WuDunn D, Alfonso E, Palmberg P F
Bascom Palmer Eye Institute, University of Miami School of Medicine, Florida, USA.
Ophthalmology. 1999 Feb;106(2):396-400. doi: 10.1016/S0161-6420(99)90081-7.
To evaluate corneal graft survival and intraocular pressure control in eyes that have undergone combined penetrating keratoplasty and trabeculectomy with mitomycin C (MMC).
Retrospective noncomparative case series.
Penetrating keratoplasty combined with trabeculectomy with MMC and other surgical procedures.
Twenty-four eyes of 22 patients undergoing combined penetrating keratoplasty and trabeculectomy with mitomycin C.
Corneal graft clarity and intraocular pressure control.
The cumulative probability of corneal graft survival was 85% at 1 year and 60% at 2 years. The cumulative probability of adequate pressure control was 67% at 3 months, 55% at 12 months, and 50% at 24 months. The incidence of bleb failure was higher in cases involving additional concomitant procedures, such as anterior vitrectomy, lens implantation or exchange, and drainage tube implantation.
Combined penetrating keratoplasty and trabeculectomy with mitomycin C is associated with good corneal graft survival but also a risk of early failure of intraocular pressure control. Other concomitant procedures during the combined penetrating keratoplasty/trabeculectomy may increase the risk of early bleb failure.
评估接受穿透性角膜移植术联合丝裂霉素C（MMC）小梁切除术的眼睛的角膜移植存活率和眼压控制情况。
回顾性非对照病例系列。
穿透性角膜移植术联合MMC小梁切除术及其他手术操作。
22例接受穿透性角膜移植术联合丝裂霉素C小梁切除术患者的24只眼睛。
角膜移植清晰度和眼压控制情况。
角膜移植1年时的累积存活率为85%，2年时为60%。眼压得到充分控制的累积概率在3个月时为67%，12个月时为55%，24个月时为50%。在涉及其他伴随手术（如前部玻璃体切除术、晶状体植入或置换以及引流管植入）的病例中，滤过泡失败的发生率更高。
穿透性角膜移植术联合丝裂霉素C小梁切除术与良好的角膜移植存活率相关，但也存在眼压控制早期失败的风险。穿透性角膜移植术/小梁切除术联合其他伴随手术可能会增加早期滤过泡失败的风险。
