Nemanqani D, Mourad W A
Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Diagn Cytopathol. 1999 Feb;20(2):67-9. doi: 10.1002/(sici)1097-0339(199902)20:2<67::aid-dc4>3.0.co;2-d.
The cytomorphologic features of fine-needle aspirates (FNA) of liposarcomas have not been fully characterized. In the current study, we attempted to identify cytological attributes of liposarcoma in FNA. Twelve FNAs of histologically proven liposarcomas were used for this study. They included 10 myxoid and two well-differentiated liposarcomas. Four cytological criteria were chosen for evaluation. These included a complex capillary network, increased cellularity, the presence of a metachromatic stroma for myxoid liposarcoma, and finally the identification of lipoblasts. Eighteen FNAs of lipomas and 17 FNAs of nonlipomatous soft-tissue sarcomas were used as controls for evaluation of the same features. The diagnosis of liposarcoma had been rendered on FNA in 7 cases (58%). The diagnosis was suggested in 3 cases (25%), and a suggestion of sarcoma was rendered in 2 cases. Complex capillary networks were identified in 9 of 12 cases (75%); this was seen in 8 of the 10 myxoid liposarcomas and 1 of the 2 well-differentiated neoplasms. Increased cellularity was seen in 7 of 12 cases (58%), metachromatic stroma was seen in 3 of 12 cases (25%), and lipoblasts were identified in 4 of 12 cases (33%). None of the lipomas or sarcomas exhibited a complex capillary network. When capillaries were identified in lipomas, they were straight, with minimal branching. The lipomas did not show evidence of increased cellularity in any cases. Metachromatic stroma was more frequently seen in the nonlipomatous sarcomas than in the liposarcomas. No lipoblasts were identified in any of the control FNAs.
脂肪肉瘤细针穿刺抽吸物（FNA）的细胞形态学特征尚未完全明确。在本研究中，我们试图确定FNA中脂肪肉瘤的细胞学特征。本研究使用了12例经组织学证实的脂肪肉瘤的FNA样本。其中包括10例黏液样脂肪肉瘤和2例高分化脂肪肉瘤。选择了四项细胞学标准进行评估。这些标准包括复杂的毛细血管网络、细胞增多、黏液样脂肪肉瘤中异染性基质的存在，以及最后脂肪母细胞的识别。18例脂肪瘤的FNA样本和17例非脂肪瘤性软组织肉瘤的FNA样本用作对照，以评估相同的特征。7例（58%）FNA样本诊断为脂肪肉瘤。3例（25%）提示诊断，2例提示为肉瘤。12例中有9例（75%）发现复杂的毛细血管网络；10例黏液样脂肪肉瘤中有8例以及2例高分化肿瘤中有1例出现这种情况。12例中有7例（58%）出现细胞增多，12例中有3例（25%）出现异染性基质，12例中有4例（33%）识别出脂肪母细胞。脂肪瘤或肉瘤均未表现出复杂的毛细血管网络。当在脂肪瘤中发现毛细血管时，它们是直的，分支极少。脂肪瘤在任何情况下均未显示细胞增多的迹象。非脂肪瘤性肉瘤比脂肪肉瘤更常出现异染性基质。在任何对照FNA样本中均未识别出脂肪母细胞。
