Use of autologous fibrin glue in dermatologic surgery: application of skin graft and second intention healing.

OBJECTIVE

To evaluate the efficiency of biological sealant, an autologous fibrin glue, in dermatological surgery.

DESIGN

Randomized clinical trial.

SETTING

The Dermatology Service of Hospital das Clinicas, Universidade de Campinas (UNICAMP), referral center.

PATIENTS

14 patients with malign epithelial cutaneous tumors participated in the evaluation, each having two tumors, generally facial and symmetrical, in order to perform a comparative evaluation on the same individual.

PROCEDURES

The glue was prepared beforehand with a sample of autologous blood. Surgical extirpation of the tumor was followed by grafts or second intention healing.

OUTCOMES

The efficiency of the sealant was then evaluated in relation to hemostasis, adhesion, surgical time and evolution of the granulation tissue, clinically and histologically.

RESULTS

Immediate hemostasis and graft adhesion, with a significant reduction of surgical time, and in the open wounds there was immediate hemostasis and a clinical increase in granulation tissue, but with no histological differences among the groups on the 7th day.

CONCLUSION

It is an adjuvant resource in skin cancer surgery.