大鼠肝动脉栓塞诱导的肝微循环变化：原始研究
Hepatic microcirculatory changes induced by hepatic artery embolization in rats: original investigation.
作者信息
Koda Y, Kan Z, Wallace S, Kaminou T, Nakamura K, Yamada R
机构信息
Department of Radiology, Osaka City University Medical School, Osaka, Japan.
出版信息
Invest Radiol. 1999 Feb;34(2):160-6. doi: 10.1097/00004424-199902000-00010.
RATIONALE AND OBJECTIVES
To evaluate the effects of hepatic artery embolization (HAE), hepatic microcirculatory changes induced by HAE were assessed quantitatively in rats.
METHODS
Using in vivo microscopy, the blood-flow velocity (BFV) through terminal portal venules (TPVs) and terminal hepatic venules (THVs) was measured during HAE with gelatin sponge powder (GSP), iodized oil (Lipiodol, 0.1, 0.2, and 0.4 mL/kg), or 0.1 mL/kg Lipiodol followed by GSP.
RESULTS
After HAE with GSP, BFV through TPVs decreased significantly, but BFV through THVs did not decrease. After HAE with Lipiodol (0.2 and 0.4 mL/kg), BFV through TPVs decreased significantly, but BFV through THVs did not. After HAE with Lipiodol followed by GSP, BFV through both TPVs and THVs decreased significantly.
CONCLUSIONS
Neither GSP nor Lipiodol adversely affects hepatic microcirculation when administered alone; however, HAE with a combination of Lipiodol and GSP does adversely affect hepatic microcirculation.
原理与目的
为评估肝动脉栓塞术（HAE）的效果，对大鼠HAE诱导的肝脏微循环变化进行了定量评估。
方法
采用体内显微镜技术，在使用明胶海绵粉（GSP）、碘化油（碘油，0.1、0.2和0.4 mL/kg）或0.1 mL/kg碘油后再用GSP进行HAE期间，测量通过终末门静脉小支（TPV）和终末肝静脉小支（THV）的血流速度（BFV）。
结果
用GSP进行HAE后，通过TPV的BFV显著降低，但通过THV的BFV未降低。用碘油（0.2和0.4 mL/kg）进行HAE后，通过TPV的BFV显著降低，但通过THV的BFV未降低。用碘油后再用GSP进行HAE后，通过TPV和THV的BFV均显著降低。
结论
单独使用GSP或碘油均不会对肝脏微循环产生不利影响；然而，碘油和GSP联合进行HAE会对肝脏微循环产生不利影响。
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