Belousov Iu B, Savenkov P M, Sidel'man A A, Parfenov A S, Savenkov M P
Kardiologiia. 1978 Aug;18(8):36-43.
Peripheral atherosclerosis was treated in 178 patients: 90 were given pyridinol carbamate for 2--4 months, 40 pentoxyphylline, 30 cetedil, and 18 received butalamine. in intermittent claudication pyridinol carbamate and trental proved most effective, cetedil (straten) was less effective. The favourable effect of pyridinol carbamate is associated with its action both on the state of microcirculation and on the content of lipids. A significant decrease in the level of blood triglycerides was observed during treatment with pyridinol carbamate. Pentoxyphylline reduced blood viscosity and platelet aggregation in patients with peripheral atherosclerosis but had no effect on the blood lipid content. Cetedil did not reduce blood viscosity although it decreased the aggregation of erythrocytes and inhibited the second phase of platelet aggregation. The objective criterion for the improvement of circulation in the affected extremities was increased tolerance to load, particularly in medication with pyridinol carbamate and trental.
178例患者接受了外周动脉粥样硬化治疗：90例给予卡胺匹林治疗2 - 4个月，40例给予己酮可可碱，30例给予西替地尔，18例给予布他拉明。在间歇性跛行中，卡胺匹林和曲克芦丁被证明最有效，西替地尔（斯特拉坦）效果较差。卡胺匹林的有益作用与其对微循环状态和脂质含量的作用有关。在用卡胺匹林治疗期间，观察到血液甘油三酯水平显著降低。己酮可可碱降低了外周动脉粥样硬化患者的血液粘度和血小板聚集，但对血脂含量没有影响。西替地尔虽然降低了红细胞聚集并抑制了血小板聚集的第二阶段，但并没有降低血液粘度。改善患肢血液循环的客观标准是对负荷的耐受性增加，特别是在使用卡胺匹林和曲克芦丁治疗时。
