Jallut O, Hessler C
Schweiz Med Wochenschr. 1976 Jul 3;106(27):918-22.
The prognosis of breast cancer is the result of many factors, among which the mass of the tumor at the time of diagnosis remains the most significant: small tumors have a better prognosis than larger ones and are less often accompanied by positive lymph nodes. It is therefore justifiable to search for them systematically by breast examination of all patients over 30. Large-scale mass screening campains in the USA, with clinical and mammographic examination of tens of thousands of women, have proven that it is possible to detect more "early" cancers and reduce general mortality in the groups studied. The number of cancers thus detected is nevertheless so small that it does not justify the investment of so much labour and money in this kind of campaign. Systematic breast examination at regular intervals (6 months to 1 year) with regular mammographies should be confined to patients in the high risk groups: women who have already undergone surgery for cancer of one breast, and patients with a marked family history of breast cancer. For the rest of the female population, the solution seems obvious: every physician should get into the habit of performing regular clinical examination of the breasts. Most gynecologists are already doing so, but they only examine a small part of the population. The most important role in the detection of breast cancer falls to the internists and the general practitioners: they should assume responsibility for all their patients' breasts, in the same manner as they do for heart and lung examinations. They will then request additional examinations (mammography, thermography) as soon as clinical examination reveals a pathological finding. The results of GILBERTSEN [5] confirm that clinical examination remains the most valuable and least expensive method for breast cancer detection.
乳腺癌的预后受多种因素影响,其中诊断时肿瘤的大小仍是最重要的因素:小肿瘤的预后比大肿瘤好,且较少伴有淋巴结阳性。因此,对所有30岁以上的患者进行乳房检查以系统地寻找小肿瘤是合理的。美国开展的大规模群体筛查活动,对数以万计的女性进行了临床和乳房X光检查,结果证明在受研究群体中能够检测出更多“早期”癌症并降低总体死亡率。然而,通过这种筛查活动检测出的癌症数量极少,以至于投入如此多的人力和资金并不合理。定期(6个月至1年)进行乳房系统检查并定期进行乳房X光检查应仅限于高危人群:曾因一侧乳腺癌接受手术的女性以及有明显乳腺癌家族史的患者。对于其他女性群体,解决办法似乎很明显:每位医生都应养成定期对乳房进行临床检查的习惯。大多数妇科医生已经在这样做,但他们只检查了一小部分人群。乳腺癌检测中最重要的角色落在了内科医生和全科医生身上:他们应该像检查心脏和肺部一样,对所有患者的乳房负责。一旦临床检查发现病理结果,他们就应要求进行进一步检查(乳房X光检查、热成像检查)。吉尔伯森[5]的研究结果证实,临床检查仍然是检测乳腺癌最有价值且最经济的方法。