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Cholinomimetic teratogens. IV. Effects of the genotype for muscular dystrophy in chickens.

作者信息

Landauer W, Clark E M, Larner M M

出版信息

Teratology. 1976 Dec;14(3):281-5. doi: 10.1002/tera.1420140303.

DOI:10.1002/tera.1420140303
PMID:996775
Abstract

Embryos of a family of chickens homozygous for muscular dystrophy (md/md) reacted with a higher incidence of malformations to treatment with carbachol than did White Leghorn embryos. The same difference in response of embryos from the two stocks occurred after treatment with sulfanilamide. Embryos of reciprocal crosses between these two stocks differed greatly, however, in their response to carbachol, F1 embryos from dystrophic hens producing a much higher incidence of malformations than did those from Leghorn hens. In contrast, both F1 sibs reacted similarly to sulfanilamide, the teratogenic effects being intermediate between those of embryos from the parent stocks.

摘要

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