小鼠微小病毒DNA串联体连接片段体外切割的肿瘤转化相关刺激作用
Neoplastic transformation-associated stimulation of the in vitro resolution of concatemer junction fragments from minute virus of mice DNA.
作者信息
Kuntz-Simon G, Bashir T, Rommelaere J, Willwand K
机构信息
Deutsches Krebsforschungszentrum, Department of Applied Tumor Virology, Abt. F0100 and Formation INSERM U375, Heidelberg, Germany.
出版信息
J Virol. 1999 Mar;73(3):2552-8. doi: 10.1128/JVI.73.3.2552-2558.1999.
Abstract
Minute virus of mice (MVM) shows an oncotropic behavior reflected by its ability to amplify its genome more efficiently in a number of transformed versus normal cells. In vivo and in vitro studies revealed that the major effect of cell transformation on MVM DNA replication occurs at the level of double-stranded replicative-form amplification. In particular, resolution of MVM DNA concatemers into monomers was found to be highly sensitive to neoplastic transformation.
摘要
小鼠微小病毒（MVM）表现出一种亲肿瘤行为，这体现在它在一些转化细胞与正常细胞中更有效地扩增其基因组的能力上。体内和体外研究表明，细胞转化对MVM DNA复制的主要影响发生在双链复制型扩增水平。特别是，发现MVM DNA串联体解析为单体对肿瘤转化高度敏感。
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Neoplastic transformation-associated stimulation of the in vitro resolution of concatemer junction fragments from minute virus of mice DNA.小鼠微小病毒DNA串联体连接片段体外切割的肿瘤转化相关刺激作用
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