眼科粘弹剂的物理化学性质对从软性滴管瓶中挤出的液滴重量的影响。
Influence of the physico-chemical properties of ophthalmic viscolysers on the weight of drops dispensed from a flexible dropper bottle.
作者信息
Van Santvliet L, Ludwig A
机构信息
Department of Pharmaceutical Sciences, Laboratory of Pharmaceutical Technology and Biopharmacy, University of Antwerp (UIA), Universiteitsplein 1, B-2610 Antwerpen (Wilrijk), Belgium.
出版信息
Eur J Pharm Sci. 1999 Mar;7(4):339-45. doi: 10.1016/s0928-0987(98)00036-0.
The present study investigated the influence of the rheological behaviour, the viscoelasticity and surface tension of various viscolysers on the weight of drops dispensed from a commercially available flexible dropper bottle. Furthermore, the effect of the concentration and molecular weight of some viscolysers and the angle at which the dropper bottle is held, were studied. Up to a value of 25 mPa x s, the viscosity and the rheological behaviour of the solution had no significant influence on the drop weight under conditions simulating patient manipulation. The lower the dynamic surface tension of the solution, however, the lower the weight of drops delivered. The dispensing angle (90 or 45 degrees) of the dropper bottle, on the other hand, had an impact on the weight of drops dispensed.
本研究调查了各种增稠剂的流变行为、粘弹性和表面张力对市售柔性滴管瓶所滴出液滴重量的影响。此外，还研究了一些增稠剂的浓度和分子量以及滴管瓶握持角度的影响。在模拟患者操作的条件下，溶液的粘度和流变行为在高达25 mPa·s的值时对液滴重量没有显著影响。然而，溶液的动态表面张力越低，滴出的液滴重量就越低。另一方面，滴管瓶的滴出角度（90度或45度）对滴出液滴的重量有影响。
Zotero 插件