Goto R, Kawashima R, Ito H, Koyama M, Sato K, Ono S, Yoshioka S, Fukuda H
Department of Nuclear Medicine and Radiology, Tohoku University, Sendai, Japan.
Ann Nucl Med. 1998 Dec;12(6):333-9. doi: 10.1007/BF03164922.
The purpose of this study was to examine the normal distribution patterns of 99mTc-HMPAO (HMPAO) in young and aged normal individuals and to clarify differences between the distribution patterns of the two groups by means of an anatomical standardization technique. The tracer distribution was measured with HMPAO and SPECT in 18 normal subjects; age range 20-81 yrs. SPECT images were globally normalized by averaging whole brain radioactivity counts to 100 counts/voxel. The SPECT images for each subject were transformed into the standard brain anatomy by means of a computerized brain atlas, together with each subject's CT images. Mean and SD images for young (28.8 +/- 6.4 yrs) and aged groups (62.3 +/- 10.2 yrs) were then calculated on a voxel-by-voxel basis. Statistically significant differences between young and aged groups were observed in the relative tracer distribution patterns. In the aged group, relative decreases were found in the cortical areas of the frontal and temporal lobes, limbic areas and basal ganglia regions. The results, as visualized changes in tracer distribution patterns with aging, may contribute to more accurate clinical diagnosis.
本研究的目的是检测99mTc-六甲基丙烯胺肟（HMPAO）在年轻和老年正常个体中的正常分布模式，并通过解剖标准化技术阐明两组分布模式之间的差异。用HMPAO和单光子发射计算机断层扫描（SPECT）测量了18名正常受试者（年龄范围20 - 81岁）的示踪剂分布。通过将全脑放射性计数平均到100计数/体素来对SPECT图像进行整体归一化。借助计算机脑图谱以及每个受试者的CT图像，将每个受试者的SPECT图像转换为标准脑解剖结构。然后逐体素计算年轻组（28.8±6.4岁）和老年组（62.3±10.2岁）的均值和标准差图像。在年轻组和老年组之间观察到示踪剂相对分布模式存在统计学上的显著差异。在老年组中，额叶和颞叶的皮质区域、边缘区域和基底神经节区域的相对放射性降低。这些结果，即随着衰老示踪剂分布模式的可视化变化，可能有助于更准确的临床诊断。
