Isozumi K, Izumi Y
Department of Neurology, Ashikaga Red Cross Hospital, Tochigi-ken, Japan.
Tokai J Exp Clin Med. 1998 Jun;23(3):103-17.
Recent progress in both experimental and clinical studies of cerebral infarction is outlined, and research on delayed neuronal death and ischemic penumbra is described. Development of animal models to study clinical pathophysiology is reviewed, and our focal cerebral ischemia model which has been used for many years is introduced. With elucidation of the pathophysiology of cerebral ischemia, various pharmaceutical agents have appeared recently in the clinical setting and our experimental trials on the treatment of cerebral ischemia are also introduced. From the clinical aspect, practical methods of treatment including antiplatelet therapy are explained. Cerebrovascular dementia and its prevention are also described.
概述了脑梗死实验研究和临床研究的最新进展，并描述了关于迟发性神经元死亡和缺血半暗带的研究。回顾了用于研究临床病理生理学的动物模型的发展，并介绍了我们多年来使用的局灶性脑缺血模型。随着脑缺血病理生理学的阐明，各种药物制剂最近出现在临床环境中，同时也介绍了我们关于脑缺血治疗的实验性试验。从临床角度解释了包括抗血小板治疗在内的实际治疗方法。还描述了脑血管性痴呆及其预防。
