Corcuera Pindado M T, Carbajo Pérez S, Gómez Aguado F, Roldán Contreras M, Picazo Talavera A, Alonso Martín M J
Servicio de Anatomía Patológica, Instituto de Salud Carlos III, Madrid.
An Med Interna. 1998 Dec;15(12):638-41.
Recently has been described alterations in different organs of HIV + patients treated with zidovudine (AZT), as secondary effect from drug administration.
We have developed and experimental rat model, in which the rats were administered AZT in drinking water and we have analysed the activity of enzyme isocitrate DH, of Krebs cycle, in hepatic tissue sections. Histological technique were employed and image analysis to objectivate the results.
A significant statistic decrease of the enzyme activity in those animals treated with AZT were observed, compared with the control groups.
The modification from enzyme activities related with Krebs cycle can be traduced in mitochondrial alterations, that could have direct or indirect influence in the appearance of some associated pathologies to the AZT treatment.
最近有描述称，接受齐多夫定（AZT）治疗的HIV阳性患者不同器官出现改变，这是药物给药的副作用。
我们建立了一个实验大鼠模型，给大鼠饮用含AZT的水，然后分析肝组织切片中参与三羧酸循环的异柠檬酸脱氢酶的活性。采用组织学技术并通过图像分析来客观呈现结果。
与对照组相比，观察到接受AZT治疗的动物体内该酶活性有显著统计学下降。
与三羧酸循环相关的酶活性改变可能导致线粒体改变，这可能对AZT治疗相关的某些病理状况的出现产生直接或间接影响。
