Youssef Fasheh W, Esquinas Rychen G
Unitat Integrada Hospital Clinic Sant Joan de Déu, Universidad de Barcelona.
An Esp Pediatr. 1998 Dec;49(6):582-6.
The purpose of this study was to analyze the features, treatment and evolution of middle lobe syndrome (MLS) or atelectasis syndrome in children.
Between 1992 and 1996, all cases of MLS seen in our center by our staff were followed by using a prospective study protocol.
Twenty-seven patients were studied. The average age at the onset of MLS was 3 years 1 month +/- 2 years 4 months. Recurrent pneumonia was seen in 66.7% and 44.4% had asthma and/or elevated IgE. Acute symptoms at the onset were seen in 74% of the cases, with persistent cough being the most common symptom. Complementary procedures (chest X-rays, computed tomography scans, bronchoscopy, V/P scintigraphy) demonstrated 16 cases of pneumonia, 13 of atelectasis, 7 of bronchiectasia and 4 cases with other abnormalities. Infectious etiology was the most predominant (66.7%) Bronchoscopy was performed in 8 cases and 5 of them improved immediately. Pulmonary scintigraphy was normal in those patients with radiographic residual images. All patients were initially medically treated. Three were lobectomized. Twenty-three patients healed. The younger the patient at the onset of MLS the better the cure rate.
Infectious causes were dominant in our series. Early and aggressive medical treatment may cure the majority of cases. Bronchoscopy is helpful in the diagnosis and as a therapeutic procedure. Scintigraphy could be helpful as a resolution criterion when there are residual radiographic images.
本研究旨在分析儿童中叶综合征(MLS)或肺不张综合征的特征、治疗及病情演变。
1992年至1996年期间,本中心工作人员采用前瞻性研究方案对所有MLS病例进行随访。
共研究了27例患者。MLS发病的平均年龄为3岁1个月±2岁4个月。66.7%的患者有反复肺炎,44.4%有哮喘和/或IgE升高。74%的病例起病时有急性症状,持续性咳嗽是最常见症状。辅助检查(胸部X线、计算机断层扫描、支气管镜检查、通气/灌注闪烁扫描)显示16例肺炎、13例肺不张、7例支气管扩张和4例其他异常。感染性病因最为常见(66.7%)。8例患者接受了支气管镜检查,其中5例立即好转。影像学有残留影像的患者肺闪烁扫描结果正常。所有患者最初均接受药物治疗。3例行肺叶切除术。23例患者痊愈。MLS起病时患者年龄越小,治愈率越高。
在我们的研究系列中,感染性病因占主导。早期积极的药物治疗可治愈大多数病例。支气管镜检查有助于诊断和作为一种治疗手段。当有影像学残留影像时,闪烁扫描可作为判断恢复情况的标准。