Wenisch S, Fortmann B, Steinmetz T, Kriete A, Leiser R, Bitsch I
Institute of Veterinary-Anatomy, -Histology and -Embryology, University of Giessen, Germany.
Anat Histol Embryol. 1998 Dec;27(6):393-7. doi: 10.1111/j.1439-0264.1998.tb00213.x.
A confocal laser scanning microscope (with a 543 nm laser) was used for imaging rat Purkinje cell dendritic spines at high 3-D resolution. In a nutritionally controlled study of the rat, 5 months of ethanol consumption was demonstrated to alter the spines of Purkinje cell dendrites in rat cerebellum. Intact spines showed significant elongation after ethanol exposure, whereas this neuromorphological alteration could not be detected in controls. Spine elongation could be regarded as compensative growth of spines in search of new synaptic contacts due to alcohol induced cell loss.
一台共聚焦激光扫描显微镜（配备543纳米激光器）用于以高三维分辨率对大鼠浦肯野细胞树突棘进行成像。在一项对大鼠的营养控制研究中，结果表明，5个月的乙醇摄入会改变大鼠小脑浦肯野细胞树突的树突棘。完整的树突棘在乙醇暴露后显示出显著伸长，而在对照组中未检测到这种神经形态学改变。树突棘伸长可被视为由于酒精诱导的细胞丢失，树突棘为寻找新的突触联系而进行的代偿性生长。
