Basso A M, Gioino G, Molina V A, Cancela L M
Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
Pharmacol Biochem Behav. 1999 Feb;62(2):307-14. doi: 10.1016/s0091-3057(98)00166-x.
The effect of chronic d-amphetamine sulfate (AMPH) treatment (nine daily injections, 2 mg/kg i.p.) on subsequent foot shock stress-induced immunological response was investigated. In addition, the potential role of a dopaminergic (DA) mechanism in the development of chronic AMPH-induced changes in stress-influenced immune responses was characterized. Exposure to foot shock stress decreased the percentage of T-lymphocytes, and reduced the delayed-type hypersensitivity reaction (DTH) in chronically AMPH-pretreated rats relative to vehicle-treated controls. Both of those stress-induced immunosuppressive responses were no longer evident when AMPH-pretreated rats were injected with haloperidol (HAL, 1 mg/kg i.p.) 30 min prior to each daily AMPH injection. The present findings are indicative of a modulatory role for dopamine in the facilitating process induced by AMPH on stress-induced immunosuppressive effects.
研究了慢性硫酸右苯丙胺（AMPH）治疗（每日注射9次，2mg/kg腹腔注射）对随后足部电击应激诱导的免疫反应的影响。此外，还对多巴胺能（DA）机制在慢性AMPH诱导的应激影响免疫反应变化发展中的潜在作用进行了表征。与载体处理的对照组相比，暴露于足部电击应激会降低慢性AMPH预处理大鼠的T淋巴细胞百分比，并减少迟发型超敏反应（DTH）。当在每日AMPH注射前30分钟给AMPH预处理的大鼠注射氟哌啶醇（HAL，1mg/kg腹腔注射）时，这两种应激诱导的免疫抑制反应不再明显。目前的研究结果表明多巴胺在AMPH诱导的应激诱导免疫抑制作用的促进过程中具有调节作用。
