Wolvers D A, Coenen-de Roo C J, Mebius R E, van der Cammen M J, Tirion F, Miltenburg A M, Kraal G
Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands.
J Immunol. 1999 Feb 15;162(4):1994-8.
Mucosal tolerance is a naturally occurring immunological phenomenon that prevents harmful inflammatory responses to ingested or inhaled environmental, predominantly nondangerous, Ags. The nasal mucosa is an extremely efficient compartment in the induction of immunological tolerance which can be exploited in Ag-specific treatment of autoimmune disease. With the use of a model Ag (OVA) and an Ag implicated in the autoimmune disease rheumatoid arthritis (human cartilage gp-39), we here show in a mouse model that the superficial cervical and internal jugular lymph nodes that drain the nasal mucosa are instrumental in the induction of tolerance. Removal of these lymph nodes abrogates tolerance induction, which can be restored by transplantation of superficial cervical lymph nodes, but not of peripheral lymph nodes. The results indicate that lymph nodes that directly drain the nasal mucosa constitute a unique microenvironment which favors the induction of immunological tolerance.
黏膜耐受是一种自然发生的免疫现象，可防止对摄入或吸入的环境抗原（主要是无害抗原）产生有害的炎症反应。鼻黏膜是诱导免疫耐受的一个极其有效的部位，可用于自身免疫性疾病的抗原特异性治疗。通过使用模型抗原（卵清蛋白）和一种与自身免疫性疾病类风湿性关节炎相关的抗原（人软骨糖蛋白-39），我们在小鼠模型中发现，引流鼻黏膜的颈浅淋巴结和颈内静脉淋巴结在诱导耐受中起重要作用。切除这些淋巴结会消除耐受诱导，而通过移植颈浅淋巴结而非外周淋巴结可恢复耐受诱导。结果表明，直接引流鼻黏膜的淋巴结构成了一个独特的微环境，有利于诱导免疫耐受。
