Tanigawa K, Sugiyama K, Matsuyama H, Nakao H, Kohno K, Komuro Y, Iwanaga Y, Eguchi K, Kitaichi M, Takagi H
Department of Internal Medicine, Kohseikai Hospital, Nagasaki University School of Medicine, Nagasaki, Japan.
Respiration. 1999;66(1):69-72. doi: 10.1159/000029341.
A 35-year-old woman with a 6-month history of ulcerative colitis and treatment with oral mesalazine (5-aminosalicylic acid) developed dry cough, low-grade fever and bilaterally wandering pulmonary infiltrates. Improvement in clinical symptoms and radiological abnormalities occurred spontaneously after discontinuation of mesalazine. The transbronchial lung biopsy demonstrated the organizing stage of eosinophilic pneumonia. Drug lymphocyte stimulation test was positive for mesalazine and negative for sulfasalazine and sulfapyridine. The present case indicates that although mesalazine-induced eosinophilic pneumonia is an extremely rare entity, its possibility should be fully considered in patients developing unexplained respiratory symptoms while on mesalazine therapy.
一名35岁女性，有6个月溃疡性结肠炎病史，一直口服美沙拉嗪（5-氨基水杨酸）治疗，出现干咳、低热及双侧游走性肺部浸润影。停用美沙拉嗪后，临床症状及影像学异常自发改善。经支气管肺活检显示为嗜酸性粒细胞性肺炎的机化期。药物淋巴细胞刺激试验显示美沙拉嗪阳性，柳氮磺胺吡啶和磺胺吡啶阴性。本病例表明，尽管美沙拉嗪诱发的嗜酸性粒细胞性肺炎极为罕见，但在接受美沙拉嗪治疗的患者出现不明原因的呼吸道症状时，应充分考虑其可能性。
