Vasilev D, Konstantinov S, Konstantinova Zh, Nachkov Ia, Karaivanova M, Stamenova P
Khirurgiia (Sofiia). 1998;51(3):36-9.
Thus far, a sufficiently effective cerebroprotective substances has not been discovered. Glutamate overproduction plays a key role in ischemic brain lesion. Ketamine is assigned to the group of commonly used clinical anesthetics, being also familiar as NMDA antagonist. Sodium fluoride-induced cerebral ischemia in mice is used as a model of circulatory ischemic lesion. As shown by the experimental data, simultaneous administration of NaF + ketamine has no effect whatsoever on the survivorship of animals, as compared to that in the control group treated with NaF alone. Beforehand treatment of mice with 150 mg/kg ketamine brings about considerable prolongation of the survival term (15 per cent of the animals survive for more than 2 hours). The inference is reached that ketamine is endowed with cerebroprotective activity largely attributable to glutamate antagonism at the level of ischemia involved neurons.
迄今为止，尚未发现一种足够有效的脑保护物质。谷氨酸过度产生在缺血性脑损伤中起关键作用。氯胺酮属于常用的临床麻醉剂类别，也是广为人知的NMDA拮抗剂。氟化钠诱导的小鼠脑缺血被用作循环缺血性损伤的模型。实验数据表明，与单独用氟化钠处理的对照组相比，同时给予氟化钠+氯胺酮对动物的存活率没有任何影响。用150mg/kg氯胺酮预先处理小鼠可使存活期显著延长（15%的动物存活超过2小时）。由此推断，氯胺酮具有脑保护活性，这在很大程度上归因于其在缺血相关神经元水平上对谷氨酸的拮抗作用。
