Magriples U, Chan D W, Bruzek D, Copel J A, Hsu C D
Department of Obstetrics and Gynecology, Yale University, New Haven, CT 06510, USA.
Thromb Haemost. 1999 Jan;81(1):32-4.
Thrombomodulin (TM), a marker of endothelial cell damage, has been localized to the placental syncytiotrophoblast. A prospective cohort study of twenty-five pregnant women who were admitted with a clinical diagnosis of placental abruption was undertaken. Abruption was confirmed after delivery in eight cases (Group 1). Group 2 consisted of seventeen patients with no clinical or pathologic evidence of placental abruption after delivery. TM was significantly elevated in Group 1 (71.59+/-5.35 vs. 48.29+/-3.53 ng/ml, p = 0.001). The sensitivity and specificity of TM > or =60 ng/ml as a marker for abruption was 87.5 and 76.5%, respectively. In comparison, the sensitivity of an abnormal coagulation profile, maternal Kleihauer-Betke and ultrasound in patients with abruption was 0, 16.7 and 28.6%, respectively. TM is a highly sensitive and specific marker for acute placental abruption.
血栓调节蛋白（TM）是一种内皮细胞损伤标志物，已定位至胎盘合体滋养层。对25例临床诊断为胎盘早剥的孕妇进行了一项前瞻性队列研究。8例患者（第1组）在分娩后确诊为胎盘早剥。第2组由17例分娩后无胎盘早剥临床或病理证据的患者组成。第1组的TM显著升高（71.59±5.35对48.29±3.53 ng/ml，p = 0.001）。TM≥60 ng/ml作为胎盘早剥标志物的敏感性和特异性分别为87.5%和76.5%。相比之下，胎盘早剥患者凝血指标异常、母体克雷浩-贝特克试验及超声检查的敏感性分别为0、16.7%和28.6%。TM是急性胎盘早剥的一种高度敏感和特异的标志物。
