Holle J, Freilinger G, Braun F, Menzel J, Spängler P
Wien Klin Wochenschr. 1976 Aug 13;88(15):501-4.
The effect of repeated subcutaneous injections of hydrocortisone and phenylbutazone on connective tissue formation was investigated in free rat muscle transplants. The follow-up investigation took place 4 weeks after transplantation of the long extensor muscles of the digits to the vastus lateralis group of the rectus femoris muscle. Connective tissue measurements were performed on the basis of hydroxyproline determinations. It was observed that in the untreated transplant there is twice as much connective tissue (expressed as a percentage) as in the same muscle remaining in situ. Hydrocortisone did not reduce the amount of connective tissue in the transplant. Phenylbutazone reduced the amount of connective tissue by 27%. At the same time the total weight of the transplants treated with hydrocortisone and phynylbutazone was reduced by 15% and 33% respectively. Attention is drawn to the myotoxic properties of hydrocortisone and phenylbutazone. Hence, in spite of the inhibited connective tissue formation there is no improvement in muscle fibre regeneration and their use cannot be recommended.
在大鼠游离肌肉移植实验中，研究了反复皮下注射氢化可的松和保泰松对结缔组织形成的影响。在将趾长伸肌移植至股直肌外侧肌群后4周进行随访调查。基于羟脯氨酸测定进行结缔组织测量。观察到，未处理的移植组织中的结缔组织量（以百分比表示）是留在原位的相同肌肉中的两倍。氢化可的松并未减少移植组织中的结缔组织量。保泰松使结缔组织量减少了27%。同时，用氢化可的松和保泰松处理的移植组织的总重量分别减少了15%和33%。需注意氢化可的松和保泰松的肌毒性特性。因此，尽管结缔组织形成受到抑制，但肌纤维再生并无改善，不建议使用它们。
