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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Monge P, Scheline R, Solheim E

Xenobiotica. 1976 Jul;6(7):411-23. doi: 10.3109/00498257609151654.

The metabolism of 4-(4-hydroxy-3-methoxyphenyl)butan-2-one (zingerone), a pungent principle of ginger, has been investigated in rats. 2. Oral or intraperitoneal dosage (100mg/kg) of zingerone resulted in the urinary excretion of most metabolites within 24 h, mainly as glucuronide and/or sulphate conjugates. While zingerone itself accounted for roughly 50-55% of the dose, reduction to the corresponding carbinol (11-13%) also occurred. Side chain oxidation took place at all three available sites and oxidation at the 3-position, giving rise to C6-C2 metabolites, predominated. About 95-97% of the dose was accounted for. 3. Appreciable (40% in 12 h) biliary excretion occurred. Biliary studies and studies in vitro using caecal micro-organisms indicated that several O-demethylated metabolites found in the urine are of bacterial origin.

姜的一种辛辣成分4-(4-羟基-3-甲氧基苯基)丁-2-酮（姜辣素）在大鼠体内的代谢情况已被研究。2. 给大鼠口服或腹腔注射姜辣素（100mg/kg）后，大部分代谢产物在24小时内随尿液排出，主要以葡萄糖醛酸和/或硫酸结合物的形式存在。虽然姜辣素本身约占给药剂量的50-55%，但也会还原为相应的甲醇（11-13%）。侧链氧化发生在所有三个可用位点，其中3位的氧化产生C6-C2代谢产物，占主导地位。约95-97%的给药剂量得到了解释。3. 出现了明显的胆汁排泄（12小时内为40%）。胆汁研究以及使用盲肠微生物的体外研究表明，尿液中发现的几种O-去甲基化代谢产物来源于细菌。

Monge P, Scheline R, Solheim E

Xenobiotica. 1976 Jul;6(7):411-23. doi: 10.3109/00498257609151654.

The metabolism of 4-(4-hydroxy-3-methoxyphenyl)butan-2-one (zingerone), a pungent principle of ginger, has been investigated in rats. 2. Oral or intraperitoneal dosage (100mg/kg) of zingerone resulted in the urinary excretion of most metabolites within 24 h, mainly as glucuronide and/or sulphate conjugates. While zingerone itself accounted for roughly 50-55% of the dose, reduction to the corresponding carbinol (11-13%) also occurred. Side chain oxidation took place at all three available sites and oxidation at the 3-position, giving rise to C6-C2 metabolites, predominated. About 95-97% of the dose was accounted for. 3. Appreciable (40% in 12 h) biliary excretion occurred. Biliary studies and studies in vitro using caecal micro-organisms indicated that several O-demethylated metabolites found in the urine are of bacterial origin.

姜的一种辛辣成分4-(4-羟基-3-甲氧基苯基)丁-2-酮（姜辣素）在大鼠体内的代谢情况已被研究。2. 给大鼠口服或腹腔注射姜辣素（100mg/kg）后，大部分代谢产物在24小时内随尿液排出，主要以葡萄糖醛酸和/或硫酸结合物的形式存在。虽然姜辣素本身约占给药剂量的50-55%，但也会还原为相应的甲醇（11-13%）。侧链氧化发生在所有三个可用位点，其中3位的氧化产生C6-C2代谢产物，占主导地位。约95-97%的给药剂量得到了解释。3. 出现了明显的胆汁排泄（12小时内为40%）。胆汁研究以及使用盲肠微生物的体外研究表明，尿液中发现的几种O-去甲基化代谢产物来源于细菌。