Jagenburg R, Attman P O, Aurell M, Bucht H
Scand J Urol Nephrol. 1978;12(2):133-7. doi: 10.3109/00365597809179980.
The glomerular filtration rate (GFR) has been determined in 17 patients with advanced renal insufficiency (GFR less than 15 ml/min) by different clearance techniques using creatinine, inulin and 51Cr-EDTA as filtration markers. With renal inulin clearance as reference method for GFR, endogenous renal creatinine clearance overestimated GFR by an average of 30%. Renal clearance of 51Cr-EDTA and inulin were closely correlated and thus 51Cr-EDTA is a suitable GFR marker even at low filtration rates. However, it was found that the plasma clearance of 51Cr-EDTA overestimated the GFR often by more than 100% in the range 2.6--11.2 ml/min. Renal clearance measured during 24 h was lower than 4 h renal clearance with the patient well hydrated and resting in bed. It is concluded that the precise measurement of low glomerular filtration rates requires the use of renal clearance techniques. Four-hour 51Cr-EDTA renal clearance is a suitable method for measuring and following the development of renal function in advanced renal insufficiency.
采用肌酐、菊粉和51铬-乙二胺四乙酸（51Cr-EDTA）作为滤过标志物，通过不同的清除技术，对17例晚期肾功能不全（肾小球滤过率（GFR）小于15ml/分钟）患者的GFR进行了测定。以肾脏菊粉清除率作为GFR的参考方法，内源性肾脏肌酐清除率平均高估GFR 30%。51Cr-EDTA和菊粉的肾脏清除率密切相关，因此即使在低滤过率情况下，51Cr-EDTA也是一种合适的GFR标志物。然而，发现在2.6--11.2ml/分钟范围内，51Cr-EDTA的血浆清除率常常高估GFR超过100%。在患者充分水化并卧床休息时，24小时测量的肾脏清除率低于4小时的肾脏清除率。得出的结论是，精确测量低肾小球滤过率需要采用肾脏清除技术。4小时的51Cr-EDTA肾脏清除率是测量和跟踪晚期肾功能不全患者肾功能发展的一种合适方法。
