Sjöstrand N O, Swedin G
Acta Physiol Scand. 1976 Nov;98(3):323-8. doi: 10.1111/j.1748-1716.1976.tb10317.x.
The total amount of noradrenaline (NA) in the male accessories increases with normal growth of the organs and also with the age of the rat. The ductus deferens of the old rat has about twice as high NA concentration as that of the young rat. Castration of the prepuberal rat or the puberal rat leads to retardation or cessation, respectively, of the increase in NA amount of the male genital tract. Only in the old rat does castration produce a definite decrease in NA amount of the tract. Castration always raises the NA concentration of the sex accessories. Testosterone treatment of the puberal rat or the old rat produces minor or no increase, respectively, in total amount of NA of the male sex accessories. Testosterone treatment of old prepuberally castrated rats produces a marked increase in NA content of the male organs. It is concluded that androgens have no substancial direct effect on the adrenergic innervation per se, but affects the transmitter levels of the male organs indirectly through changes in number, size and relative proportion of the target cells of the adrenergic nerves i.e. the smooth muscle cells.
雄性附属性器官中去甲肾上腺素（NA）的总量随着器官的正常生长以及大鼠年龄的增长而增加。老年大鼠的输精管中NA浓度约为幼年大鼠的两倍。对青春期前大鼠或青春期大鼠进行阉割，分别导致雄性生殖道中NA含量的增加减缓或停止。只有老年大鼠阉割后，生殖道中的NA含量才会出现明显下降。阉割总是会提高性附属器官的NA浓度。对青春期大鼠或老年大鼠进行睾酮处理，雄性性附属器官中NA的总量分别略有增加或无增加。对青春期前阉割的老年大鼠进行睾酮处理，会使雄性器官的NA含量显著增加。结论是，雄激素本身对肾上腺素能神经支配没有实质性的直接影响，而是通过改变肾上腺素能神经靶细胞（即平滑肌细胞）的数量、大小和相对比例，间接影响雄性器官的递质水平。
