Abernathy R S
Am J Dis Child. 1976 Dec;130(12):1360-2. doi: 10.1001/archpedi.1976.02120130066013.
A 51/2-month-old infant had the single problem of a bulging fontanelle. A diagnosis of cystic fibrosis with secondary hypovitaminosis A was made by the findings of high sweat chloride values and a low serum carotene level. A greatly accelerated rate of weight gain following the addition of pancreatic enzyme supplements confirmed the presence of malabsorption. The infant developed characteristic fibrosis pulmonary disease at 20 months of age. Animal studies have shown vitamin A deficiency to be associated with increased cerebrospinal fluid (CSF) pressure, diminished absorption of CSF, and pathological findings of thickening and infiltration with mucopolysaccharides of the dura mater around the arachnoid villi.
一名5个半月大的婴儿唯一的问题是囟门隆起。通过高汗液氯化物值和低血清胡萝卜素水平的检查结果，诊断为囊性纤维化伴继发性维生素A缺乏症。添加胰酶补充剂后体重增加速度大大加快，证实存在吸收不良。该婴儿在20个月大时出现了典型的肺纤维化疾病。动物研究表明，维生素A缺乏与脑脊液（CSF）压力升高、脑脊液吸收减少以及蛛网膜绒毛周围硬脑膜粘多糖增厚和浸润的病理表现有关。
