Cipolla-Neto J, Skorupa A L, Ribeiro-Barbosa E R, Bartol I, Mota S R, Afeche S C, Delagrange P, Guardiola-Lemaitre B, Canteras N S
Department of Physiology, Institute of Biomedical Sciences, University of São Paulo, Brazil.
Neuroendocrinology. 1999 Feb;69(2):97-104. doi: 10.1159/000054407.
The aim of the present investigation was to study the effect of neurotoxic ibotenic acid lesion of the retrochiasmatic area on the daily profile of pineal N-acetylserotonin and melatonin synthesis and on the pineal metabolic reactivity to nocturnal short-term retinal photostimulation. Groups of rats were killed 6 h after lights off either in the dark of immediately after being photostimulated for 1 or 15 min. Additionally, groups of rats were sacrificed at six different time points throughout the 24-hour light-dark cycle. The results suggested the presence of two functionally distinct territories in the retrochiasmatic area. The basal retrochiasmatic area, an area situated immediately ventral to the third ventricle, behind the suprachiasmatic nuclei and in front of the arcuate nucleus, is implicated in the nocturnal inhibitory process induced by short-term retinal photostimulation. The lateral retrochiasmatic area, which is situated immediately lateral to the anterior periventricular nucleus, below the anterior hypothalamic nucleus and in front of the ventromedial hypothalamic nucleus, is importantly involved in the control of the peak amplitude of the daily production of N-acetylserotonin and melatonin by the pineal gland.
本研究的目的是探讨视交叉后区神经毒性鹅膏蕈氨酸损伤对松果体N - 乙酰血清素和褪黑素合成的每日变化以及松果体对夜间短期视网膜光刺激的代谢反应性的影响。将大鼠分组，在熄灯后6小时于黑暗环境中处死，或者在光刺激1分钟或15分钟后立即处死。此外，在24小时明暗周期的六个不同时间点处死大鼠组。结果表明视交叉后区存在两个功能不同的区域。视交叉后基底区位于第三脑室正下方、视交叉上核后方和弓状核前方，与短期视网膜光刺激诱导的夜间抑制过程有关。视交叉后外侧区位于室周前核外侧、下丘脑前核下方和下丘脑腹内侧核前方，在控制松果体每日N - 乙酰血清素和褪黑素产生的峰值幅度方面起着重要作用。
