Papadimitriou J M, Robertson T A
Am J Pathol. 1976 Dec;85(3):595-608.
Reovirus 3 infection of neonatal mice, although characterized primarily by encephalitis, hepatitis, and pancreatitis, also induces an adrenalitis. Histologically, the latter is characterized initially by foci of coagulative necrosis which later enlarge and become surrounded by leukocytic infiltration. Ultrastructurally, the virus was shown to replicate in the paranuclear region of mainly adrenocortical cells but also medullary and endothelial cells. Apoptosis is the most common form of necrosis exhibited and is quickly followed by an infiltration of mononuclear phagocytes which eventually ingest the virus and the cellular debris.
呼肠孤病毒3型感染新生小鼠，虽然主要特征为脑炎、肝炎和胰腺炎，但也会引发肾上腺炎。组织学上，后者最初的特征是凝固性坏死灶，这些病灶随后扩大并被白细胞浸润包围。超微结构上，该病毒主要在肾上腺皮质细胞的核旁区域复制，但也在髓质细胞和内皮细胞中复制。凋亡是最常见的坏死形式，随后很快会有单核吞噬细胞浸润，最终吞噬病毒和细胞碎片。
