Larsson L I, Schwartz T, Lundqvist G, Chance R E, Sundler F, Rehfeld J F, Grimelius L, Fahrenkrug J, Schaffalitzky de Muckadell O, Moon N
Am J Pathol. 1976 Dec;85(3):675-84.
Eighteen endocrine pancreatic tumors were examined for the occurrence of cells producing insulin, glucagon, gastrin, human pancreatic polypeptide (HPP), and vasoactive intestinal polypeptide (VIP) and for A1 cells. More than half of the tumors were mixed, i.e., they contained more than one type of hormone-producing cell. The clinical symptoms were attributable only to one of the hormones produced by the mixed tumors. Three of four tumors causing the watery diarrhea syndrome contained both VIP and HPP cells. In one such tumor there was a strong predominance of HPP cells; the serum HPP levels of this patient were a thousandfold elevated, whereas her VIP levels were within the normal range. Several lines of evidence point to HPP as a possible agent causing the watery diarrhea syndrome. In many of our patients, HPP cells hyperplasia was present in the extratumoral pancreas. Such hyperplasia may give rise to the raised serum HPP levels seen in many patients having endocrine pancreatic tumors.
对18例胰腺内分泌肿瘤进行了检查，以确定产生胰岛素、胰高血糖素、胃泌素、人胰多肽（HPP）和血管活性肠多肽（VIP）的细胞以及A1细胞的存在情况。超过半数的肿瘤为混合性肿瘤，即它们含有不止一种类型的激素产生细胞。临床症状仅归因于混合性肿瘤产生的一种激素。导致水样腹泻综合征的4例肿瘤中有3例同时含有VIP和HPP细胞。在其中1例这样的肿瘤中，HPP细胞占绝对优势；该患者的血清HPP水平升高了1000倍，而其VIP水平在正常范围内。几条证据表明HPP可能是导致水样腹泻综合征的因素。在我们的许多患者中，肿瘤外胰腺存在HPP细胞增生。这种增生可能导致许多患有胰腺内分泌肿瘤的患者血清HPP水平升高。
