Wertlake P
Unilab, Tarzana, CA 91356, USA.
J Reprod Med. 1999 Jan;44(1):11-7.
To determine the effectiveness of AutoPap QC System rescreening of all qualified negative cervical cytologic smears with selection of approximately 10% for cytotechnologist rescreening as compared to a random selection of 10% of negative cases.
The study included 1,141,913 consecutive smears. In February 1997 an AutoPap-based QC program was implemented to select a population for rescreening. Negative cases were studied prospectively by the AutoPap QC System. Detection rates by diagnostic classification of false negative cases were compared to rates obtained using a randomly selected 10% rescreening of negative cases from the immediately preceding time period.
The AutoPap QC System was 5.2-fold more effective for the detection of high grade squamous intraepithelial lesion + false negatives, 2.0-fold for low grade squamous intraepithelial lesions, 2.8-fold for atypical squamous cells of undetermined significance and 5.1-fold for atypical glandular cells of undetermined significance.
In a large reference laboratory a QC program utilizing the AutoPap QC System was significantly more effective in the detection of false negative smears as compared to a QC program utilizing 10% random rescreening of negative smears.
确定与随机选择10%的阴性病例进行细胞技术人员复查相比，使用AutoPap质量控制（QC）系统对所有合格的阴性宫颈细胞学涂片进行复查（选择约10%进行细胞技术人员复查）的有效性。
该研究纳入了1,141,913例连续涂片。1997年2月实施了基于AutoPap的QC计划，以选择用于复查的人群。通过AutoPap QC系统对阴性病例进行前瞻性研究。将假阴性病例按诊断分类的检出率与使用从前一时间段随机选择10%的阴性病例进行复查所获得的检出率进行比较。
AutoPap QC系统在检测高级别鳞状上皮内病变+假阴性方面的有效性高5.2倍，在检测低级别鳞状上皮内病变方面高2.0倍，在检测意义不明确的非典型鳞状细胞方面高2.8倍，在检测意义不明确的非典型腺细胞方面高5.1倍。
在一个大型参考实验室中，与使用对阴性涂片进行10%随机复查的QC计划相比，使用AutoPap QC系统的QC计划在检测假阴性涂片方面显著更有效。
