Mohr D C, Likosky W, Boudewyn A C, Marietta P, Dwyer P, Van der Wende J, Goodkin D E
University of California, San Francisco, Mt. Zion MS Center 94115-1642, USA.
Mult Scler. 1998 Dec;4(6):487-9. doi: 10.1177/135245859800400605.
This study examines the course of patient-reported side effects during the first 4 months of treatment for multiple sclerosis (MS) with interferon beta-1a (IFN beta-1a), and the relationship of those side effects to discontinuation of medication. Flu-like symptoms, muscle aches and chills decreased over the first 2 months of treatment but did not change over the second 2 months. Loss of feeling or numbness, tingling and depression increased over 4 months, however these side effects were generally mild. Loss of feeling or numbness and tingling at 2 month follow-up were significantly related to discontinuation of IFN beta-1a by 4 month follow-up.
本研究调查了使用β-1a干扰素（IFNβ-1a）治疗多发性硬化症（MS）的前4个月中患者报告的副作用病程，以及这些副作用与停药之间的关系。流感样症状、肌肉疼痛和寒战在治疗的前2个月有所减轻，但在接下来的2个月中没有变化。感觉丧失或麻木、刺痛和抑郁在4个月内有所增加，然而这些副作用通常较轻。在2个月随访时出现的感觉丧失或麻木以及刺痛与在4个月随访时停用IFNβ-1a显著相关。
