Ruiz-Martínez J, Martínez Pérez-Balsa A, Ruibal M, Urtasun M, Villanua J, Martí Massó J F
Department of Neurology, Hospital Ntra. Sra. de Aránzazu, San Sebastián, Spain.
Neuroradiology. 1999 Jan;41(1):40-3. doi: 10.1007/s002340050702.
We report a 61-year-old alcoholic man who presented with subacute physical deterioration and severe dysarthria. MRI, suggestive of corpus callosum demyelination with associated white matter involvement in both cerebral hemispheres, indicated the diagnosis of Marchiafava-Bignami disease. During his stay in hospital the patient showed remarkable improvement, and was discharged 22 days after admission. On MRI 2 months later, the extracallosal lesions had disappeared. This case raises questions about some previous ideas on this disease, such as the prognosis of its acute forms and the significance of the extracallosal lesions seen on neuroimaging.
我们报告了一名61岁的男性酗酒者，他出现了亚急性身体衰退和严重构音障碍。MRI提示胼胝体脱髓鞘并伴有双侧大脑半球白质受累，这表明诊断为马奇亚法瓦-比尼亚米病。在患者住院期间，病情显著改善，入院22天后出院。2个月后的MRI显示，胼胝体外病变已消失。该病例引发了对关于这种疾病的一些先前观点的质疑，例如其急性形式的预后以及神经影像学上所见胼胝体外病变的意义。
