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一种治疗脑高级别胶质瘤的新方法。

A new treatment for high grade gliomas of the brain.

作者信息

Brady L W

机构信息

Department of Radiation Oncology, Allegheny University of the Health Sciences Allegheny University Hospitals, Hahnemann, Philadelphia, USA.

出版信息

Bull Mem Acad R Med Belg. 1998;153(5-6):255-61; discussion 261-2.

PMID:9988932
Abstract

The data confirmed the fact that repeated administrations of iodine-125 labeled anti-epidermal growth factor receptor 425 is safe and may have benefited the management of primary high grade gliomas of the brain as well as recurrent astrocytomas. At present, a randomized control phase III trial is in the process of being initiated to evaluate the benefits that would accrue in a controlled environment.

摘要

数据证实了以下事实

重复给予碘-125标记的抗表皮生长因子受体425是安全的,并且可能有助于原发性高级别脑胶质瘤以及复发性星形细胞瘤的治疗。目前,一项随机对照III期试验正在启动过程中,以评估在可控环境中可能产生的益处。

相似文献

1
A new treatment for high grade gliomas of the brain.一种治疗脑高级别胶质瘤的新方法。
Bull Mem Acad R Med Belg. 1998;153(5-6):255-61; discussion 261-2.
2
Malignant astrocytomas treated with iodine-125 labeled monoclonal antibody 425 against epidermal growth factor receptor: a phase II trial.
Int J Radiat Oncol Biol Phys. 1992;22(1):225-30. doi: 10.1016/0360-3016(92)91009-c.
3
The use of epidermal growth factor receptor-425 monoclonal antibodies radiolabeled with iodine-125 in the adjuvant treatment of patients with high grade gliomas of the brain.用碘-125标记的表皮生长因子受体-425单克隆抗体在脑高级别胶质瘤患者辅助治疗中的应用。
Recent Results Cancer Res. 1996;141:183-92. doi: 10.1007/978-3-642-79952-5_13.
4
Multiple infusions of anti-epidermal growth factor receptor (EGFR) monoclonal antibody (EMD 55,900) in patients with recurrent malignant gliomas.复发性恶性胶质瘤患者多次输注抗表皮生长因子受体(EGFR)单克隆抗体(EMD 55,900)。
Eur J Cancer. 1996 Apr;32A(4):636-40. doi: 10.1016/0959-8049(95)00592-7.
5
Retreatment of intracranial gliomas.
South Med J. 1994 Feb;87(2):211-4. doi: 10.1097/00007611-199402000-00013.
6
High grade astrocytomas in children: Hartford Hospital experience.
Conn Med. 1991 Mar;55(3):135-8.
7
Brachytherapy and hyperthermia for malignant astrocytomas.恶性星形细胞瘤的近距离放射治疗和热疗
Semin Oncol. 1994 Apr;21(2):186-97.
8
[Association of 5-FU, CDDP and hypofractionated radiotherapy in recurrences of subtentorial astrocytomas and malignant gliomas in adults].
Bull Cancer Radiother. 1990;77(1):53-9.
9
Immunotherapy for recurrent malignant glioma: an interim report on survival.复发性恶性胶质瘤的免疫治疗:生存情况中期报告。
Neurol Res. 1990 Dec;12(4):265-73. doi: 10.1080/01616412.1990.11739955.
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Treatment of children with high grade glioma with nimotuzumab: a 5-year institutional experience.尼莫单抗治疗高级别脑胶质瘤患儿:5 年机构经验。
MAbs. 2013 Mar-Apr;5(2):202-7. doi: 10.4161/mabs.22970.

引用本文的文献

1
Immunotherapy of malignant brain tumors.恶性脑肿瘤的免疫治疗
Immunol Rev. 2008 Apr;222:70-100. doi: 10.1111/j.1600-065X.2008.00603.x.
2
Molecular strategies for the treatment of malignant glioma--genes, viruses, and vaccines.治疗恶性胶质瘤的分子策略——基因、病毒与疫苗
Neurosurg Rev. 2008 Apr;31(2):141-55; discussion 155. doi: 10.1007/s10143-008-0121-0. Epub 2008 Feb 8.