Elman I, Sigler M, Kronenberg J, Lindenmayer J P, Doron A, Mendlovic S, Gaoni B
Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY, USA.
Isr J Psychiatry Relat Sci. 1998;35(4):280-6.
The goal of this study was to investigate the characteristics of schizophrenic patients with a history of childhood attention deficit hyperactivity disorder (ADHD). The study was performed on 37 adolescent patients meeting the DSM-III-R criteria for schizophrenia and ADHD and 40 controls with schizophrenia only. Schizophrenic patients who were diagnosed in childhood as suffering from ADHD had more prominent developmental disturbances in infancy, more insidious course of schizophrenia, failed to respond to neuroleptics and had poorer outcome as compared to patients with schizophrenia only. The results of this study indicate that schizophrenia subsequent to childhood ADHD has a poor prognosis as compared to schizophrenia only.
本研究的目的是调查有童年注意缺陷多动障碍（ADHD）病史的精神分裂症患者的特征。该研究对37名符合DSM-III-R精神分裂症和ADHD标准的青少年患者以及40名仅患有精神分裂症的对照者进行。童年期被诊断患有ADHD的精神分裂症患者与仅患有精神分裂症的患者相比，在婴儿期有更明显的发育障碍，精神分裂症病程更隐匿，对抗精神病药物无反应，且预后更差。本研究结果表明，与仅患精神分裂症相比，童年ADHD后患精神分裂症的预后较差。
