Wilczek H
III. Interní klinika 1. LF UK a VFN, Praha.
Cas Lek Cesk. 1998 Nov 30;137(23):725-8.
The author presents a review of experience with substitution treatment in opiate dependence. Methadone treatment is most frequently used. An individual daily dose and long-term substitution are desirable for stabilization and motivation of patients included in the methadone programme. Interaction of methadone with some drugs affects the methadone metabolism and calls for a change of the methadone dose and must not be omitted. In addition to methadone there are also other types of pharmacotherapy of opiate dependence (acetylmethadol, buprenorphine). In the Czech Republic in 1997 in the General Faculty Hospital Prague the methadone programme was started. The importance of methadone substitution treatment is beyond doubt and involves improvement of the psychosocial and health status of addicts, gives an opportunity of resocialization and reintegration into society.
作者介绍了阿片类药物依赖替代治疗的经验回顾。美沙酮治疗是最常用的。对于美沙酮项目中的患者，为实现病情稳定和激发治疗积极性，每日个体化剂量及长期替代治疗是可取的。美沙酮与某些药物的相互作用会影响美沙酮代谢，需要改变美沙酮剂量，这一点绝不能忽视。除美沙酮外，还有其他类型的阿片类药物依赖药物治疗（醋美沙朵、丁丙诺啡）。1997年，在捷克共和国布拉格综合大学医院启动了美沙酮项目。美沙酮替代治疗的重要性毋庸置疑，它能改善成瘾者的心理社会和健康状况，为重新融入社会提供机会。
