Shabb N S, Tawil A, Mufarrij A, Obeid S, Halabi J
Department of Pathology, American University of Beirut, Medical Center, Lebanon.
Acta Cytol. 1997 Jul-Aug;41(4 Suppl):1284-8. doi: 10.1159/000333521.
Mammary carcinoma with osteoclastlike giant cells (OCLGCs) is a rare tumor. Few reports on the fine needle aspiration (FNA) findings are available. This case had cytologic findings overlapping with benign breast disease.
A 50-year-old woman presented with multiple masses in her right breast and a 2-cm right axillary lymph node. Cytologic scrapings and FNA of the same breast mass showed large cohesive, two-dimensional epithelial cells with a uniform distribution of small, bland nuclei. Discohesion, single cells with features of malignancy, cytologic atypia and mitosis were lacking. Many OCLGCs were present.
The cytologic features of this rare type of breast carcinoma need to become familiar to pathologists to avoid a false negative diagnosis.
伴有破骨细胞样巨细胞（OCLGCs）的乳腺癌是一种罕见肿瘤。关于细针穿刺抽吸（FNA）结果的报道很少。该病例的细胞学表现与良性乳腺疾病有重叠。
一名50岁女性，右乳有多个肿块，右腋窝有一个2厘米的淋巴结。对同一乳房肿块进行细胞学刮片和FNA检查，结果显示有大量相互黏附的二维上皮细胞，小而温和的细胞核分布均匀。未见细胞离散、具有恶性特征的单个细胞、细胞学异型性及有丝分裂。存在许多破骨细胞样巨细胞。
病理学家需要熟悉这种罕见类型乳腺癌的细胞学特征，以避免假阴性诊断。
