Kyaw Y, Hasegawa G, Takatsuka H, Shimada-Hiratsuka M, Umezu H, Arakawa M, Naito M
Second Department of Pathology, Niigata University School of Medicine, Japan.
Arch Histol Cytol. 1998 Dec;61(5):383-93. doi: 10.1679/aohc.61.383.
During pregnancy, mouse uterine epithelial cells produce and secrete a large amount of macrophage colony-stimulating factor (M-CSF/CSF-1). Macrophages accumulate and proliferate in the undecidualized endometrium of the pregnant uterus. Observations showed that macrophages expressed scavenger receptor class A (type I and type II) and class C (macrosialin). Scavenger receptors appeared to be involved in the removal of apoptotic cells in the degenerated decidual tissue. The expression of class A and class C scavenger receptor mRNAs in the uterus of pregnant mice was elevated but the expression of class B scavenger receptor (CD36) mRNA was similar to that of non-pregnant mice. The expression of various cytokines and chemokines, including M-CSF, monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein 1-alpha (MIP1-alpha), was enhanced in the uterus of pregnant mice, suggesting that these molecules regulate macrophage chemotaxis and immunological function in the uterus. These findings imply that the pregnant uterus provides a microenvironment for the recruitment, differentiation, and proliferation of macrophages and the regulation of scavenger receptor and cytokine expression for a successful pregnancy.
在怀孕期间，小鼠子宫上皮细胞产生并分泌大量巨噬细胞集落刺激因子（M-CSF/CSF-1）。巨噬细胞在妊娠子宫未发生蜕膜化的子宫内膜中积聚并增殖。观察结果显示，巨噬细胞表达A类（I型和II型）和C类清道夫受体（巨唾液酸蛋白）。清道夫受体似乎参与了退化蜕膜组织中凋亡细胞的清除。妊娠小鼠子宫中A类和C类清道夫受体mRNA的表达升高，但B类清道夫受体（CD36）mRNA的表达与未妊娠小鼠相似。包括M-CSF、单核细胞趋化蛋白-1（MCP-1）和巨噬细胞炎性蛋白1-α（MIP1-α）在内的多种细胞因子和趋化因子在妊娠小鼠子宫中的表达增强，这表明这些分子调节子宫中巨噬细胞的趋化性和免疫功能。这些发现意味着妊娠子宫为巨噬细胞的募集、分化和增殖以及清道夫受体和细胞因子表达的调节提供了一个微环境，以实现成功妊娠。
