Ho G D, Silverman L, Bercovici A, Puchalski C, Tulshian D, Xia Y, Czarniecki M, Green M, Cleven R, Zhang H, Fawzi A
Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.
Bioorg Med Chem Lett. 1999 Jan 4;9(1):7-12. doi: 10.1016/s0960-894x(98)00681-7.
Syntheses and structure-activity relationships (SAR) of cGMP selective phosphodiesterase inhibitors are discussed. Potent and selective inhibitors are produced when the C-2 position of tetracyclic guanine 1 is substituted with alkyl chains containing six carbon atoms.
讨论了环磷酸鸟苷（cGMP）选择性磷酸二酯酶抑制剂的合成及其构效关系（SAR）。当四环鸟嘌呤1的C-2位被含六个碳原子的烷基链取代时，可产生强效且选择性的抑制剂。
