硫代磷酸酯反义寡核苷酸对U937细胞中转化生长因子-β2表达的抑制作用
Inhibition of transforming growth factor-beta 2 expression with phosphorothioate antisense oligonucleotides in U937 cells.
作者信息
Shen Z J, Kim S K, Lee Y S, Lee J W, Moon B J
机构信息
Department of Biochemistry, Kyungpook National University, Taegu, Korea.
出版信息
Bioorg Med Chem Lett. 1999 Jan 4;9(1):13-8. doi: 10.1016/s0960-894x(98)00675-1.
PMID:9990448
Abstract
Four types of phosphorothioate antisense oligonucleotides for transforming growth factor-beta 2 were synthesized and tested for their antisense activity in U937 cells. The full-length phosphorothioate modified antisense analogues exhibited the highest inhibitory effects on the transforming growth factor-beta 2 expression in U937 cells.
摘要
合成了四种用于转化生长因子-β2的硫代磷酸反义寡核苷酸，并在U937细胞中测试了它们的反义活性。全长硫代磷酸修饰的反义类似物对U937细胞中转化生长因子-β2的表达表现出最高的抑制作用。
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