Mulnix J A, Van den Brom W E, Lubberink A A, de Bruijne J J, Rijnberk A
Am J Vet Res. 1976 Dec;37(12):1467-71.
Gamma camera imaging of the adrenal glands was done in 8 dogs with hyperadrenocorticism and 4 normal dogs given intravenous injections of 131I-19-iodocholesterol. In normal dogs, both adrenal glands could be visualized separately, and there was no difficulty in distinguishing among the images of normal glands, hyperplastic glands, and functional adrenal tumors. In addition, gamma camera imaging enabled the correct surgical site to be selected for removal of adrenal tumors. Hyperadrenocorticism was diagnosed in 8 dogs by evaluation of urinary 17-hydroxycorticosteroid (OHCS) excretion rates, urinary 17-OHCS and plasma 11beta-OHCS RESPONSES TO DEXAMETHASONE SUPPRESSION OF ENDOGENOUS ADRENOCORTICOTROPIN (ACTH) secretion, and plasma 11beta-OHCS response to intravenous administration of ACTH. Base line 17-OHCS excretion increased in 5 of the 8 dogs. Plasma 11beta-OHCS concentrations were not decreased by dexamethasone administration in the 4 dogs subsequently found to have adrenal tumors; however, there was an exaggerated increase in plasma 11beta-OHCS concentration after administration of ACTH in 3 of the 4 dogs which had bilateral adrenocortical hyperplasia.
对8只患有肾上腺皮质功能亢进的犬和4只正常犬静脉注射131I-19-碘胆固醇后，进行了肾上腺的γ相机成像。在正常犬中，双侧肾上腺均可单独显影，区分正常腺体、增生腺体和功能性肾上腺肿瘤的图像并无困难。此外，γ相机成像能够为肾上腺肿瘤切除选择正确的手术部位。通过评估尿17-羟皮质类固醇（OHCS）排泄率、尿17-OHCS以及血浆11β-OHCS对地塞米松抑制内源性促肾上腺皮质激素（ACTH）分泌的反应，以及血浆11β-OHCS对静脉注射ACTH的反应，诊断出8只犬患有肾上腺皮质功能亢进。8只犬中有5只的基线17-OHCS排泄增加。在随后发现患有肾上腺肿瘤的4只犬中，地塞米松给药后血浆11β-OHCS浓度未降低；然而，在4只患有双侧肾上腺皮质增生的犬中，有3只在注射ACTH后血浆11β-OHCS浓度出现过度升高。
