Bilich G L, Zenger V V
Antibiotiki. 1976 Aug;21(8):750-4.
The effect of kanamycin on the kidney function and the possibility of decreasing its side effect of pyrimidines were studied in240 children at the age of 2 month to 14 years (161 children with acute and chronic osteomyelitis and 79 children with staphylococcal destruction of the lungs). Kanamycin used in doses of 15000 and 25000 Units/kg of the body weight for 6 to 7 days in treatment of the children with staphylococcal destruction of the lungs, acute and chronic osteomyelitis had no nephrotoxic effect. Combination of kanamycin with pentoxyl, pryimidine derivative significantly improved the kidney function, which was evident from the content of the residual nitrogen in the blood serum and increased glomerural filtration. Combined use of kanamycin with pentoxyl promoted a decrease in albuminuria and leucocyturia. The data of the study provided recommendation of increased therapeutic doses of kanamycin, up to 15000--25000 Units/kg of the body weight in accordance with the recommendations under conditions of constant control of the kidney function.
对240名年龄在2个月至14岁的儿童（161名急慢性骨髓炎患儿和79名葡萄球菌性肺破坏患儿）研究了卡那霉素对肾功能的影响以及降低其嘧啶类副作用的可能性。在治疗葡萄球菌性肺破坏、急慢性骨髓炎患儿时，卡那霉素以15000和25000单位/千克体重的剂量使用6至7天，未产生肾毒性作用。卡那霉素与嘧啶衍生物潘生丁联合使用可显著改善肾功能，这从血清中残余氮含量及肾小球滤过率增加可以明显看出。卡那霉素与潘生丁联合使用可促使蛋白尿和白细胞尿减少。该研究数据建议在持续监测肾功能的条件下，根据相关建议将卡那霉素的治疗剂量增加至15000 - 25000单位/千克体重。
