[鼠疫杆菌青霉素酶的研究，其合成由R-附加体决定]
[Study of the penicillinase of the plague microbe, the synthesis of which is determined by the R-episome].
作者信息
Rozhkov K K, Mishan'kin B N
出版信息
Antibiotiki. 1976 Sep;21(9):800-5.
PMID:999263
Abstract
Penicillinase produced by a culture of the plague microbe with episomic resistance to benzylpenicillin was isolated and purified. Comparative investigation of the substrate spectrum, Michaelis constant and antigenic properties of the enzymes from the plague and dysentery microbes (R-factor donor) showed that transfer of the R-episome to the new host did not affect the investigated properties of penicillinase the synthesis of which was controlled by this episome.
摘要
分离并纯化了由对苄青霉素具有附加体抗性的鼠疫微生物培养物产生的青霉素酶。对来自鼠疫和痢疾微生物（R因子供体）的酶的底物谱、米氏常数和抗原特性进行的比较研究表明，R附加体转移到新宿主中并不影响由该附加体控制其合成的青霉素酶的所研究特性。
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