Vanderheiden B S, Zarate-Moyano C
Biol Psychiatry. 1976 Dec;11(6):755-65.
A higher incidence of erythrocyte ITP pyrophosphohydrolase deficiency was found among a psychiatric population when compared to a nonpsychiatric group of subjects. Although the incidence was highest among schizophrenics, particularly those diagnosed as paranoid, the majority of the patients did not show such deficiency. The parallelisms between ITP pyrophosphohydrolase and hypoxanthine-guanine phosphoribosyl transferase deficiencies, both characterized by the lack of availability of IMP, and correlated to behavioral disorders, suggest that irregularities of hypoxanthine nucleotides may be implicated in abnormal mental processes.
与非精神科受试者组相比，在精神科人群中发现红细胞ITP焦磷酸水解酶缺乏症的发生率更高。尽管在精神分裂症患者中发生率最高，尤其是那些被诊断为偏执型的患者，但大多数患者并未表现出这种缺乏症。ITP焦磷酸水解酶和次黄嘌呤 - 鸟嘌呤磷酸核糖转移酶缺乏症之间的相似之处，两者均以IMP可用性缺乏为特征，并与行为障碍相关，这表明次黄嘌呤核苷酸的异常可能与异常心理过程有关。
