金刚烷胺作用机制的研究。
Studies on the mechanism of action of amantadine.
作者信息
Brown F, Redfern P H
出版信息
Br J Pharmacol. 1976 Dec;58(4):561-7. doi: 10.1111/j.1476-5381.1976.tb08624.x.
Abstract
1 The effect of amantadine hydrochloride on various aspects of catecholamine metabolism in the rat brain has been investigated. 2 Amantadine failed to have any significant effect on brain concentrations of dopamine or noradrenaline even when administered daily for 9 days. 3 Amantadine had no effect on the rate of decline of noradrenaline and dopamine concentrations after alpha-methyl-p-tyrosine. 4 In vitro amantadine inhibited dopamine uptake into synaptosomes only at high concentrations, and caused little release of dopamine from synaptosomes. 5 There is no evidence from these results to suggest that the anti-Parkinsonian effect of amantadine is related to an action on dopaminergic mechanisms.
摘要
已对盐酸金刚烷胺对大鼠脑内儿茶酚胺代谢各方面的影响进行了研究。
即使每日给药9天，金刚烷胺对脑内多巴胺或去甲肾上腺素的浓度也没有任何显著影响。
金刚烷胺对α-甲基对酪氨酸处理后去甲肾上腺素和多巴胺浓度的下降速率没有影响。
在体外，金刚烷胺仅在高浓度时才抑制多巴胺摄取到突触体中，并且从突触体中释放的多巴胺很少。
从这些结果中没有证据表明金刚烷胺的抗帕金森病作用与对多巴胺能机制的作用有关。
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