多巴胺：金刚烷胺在体内从大脑释放。
Dopamine: release from the brain in vivo by amantadine.
作者信息
Von Voigtlander P F, Moore K E
出版信息
Science. 1971 Oct 22;174(4007):408-10. doi: 10.1126/science.174.4007.408.
PMID:5111993
Abstract
After dopamine stores in the caudate nucleus of cats were labeled with [(3)H]dopamine, the ventricular system was perfused with artificial cerebrospinal fluid. The addition of amantadine to the perfusing fluid caused a doserelated increase in the concentrations of [(3)H]dopamine appearing in the perfusion effluent. Subthreshold concentrations of amantadine also enhanced the efflux of [(3)H]dopamine induced by electrical stimulation of the caudate nucleus.
摘要
在用[³H]多巴胺标记猫尾状核中的多巴胺储存后，用人工脑脊液灌注脑室系统。向灌注液中添加金刚烷胺会导致灌注流出液中[³H]多巴胺浓度呈剂量相关增加。亚阈值浓度的金刚烷胺也增强了电刺激尾状核诱导的[³H]多巴胺外流。
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