Guggenheim K, Simkin A, Wolinsky I
Calcif Tissue Res. 1976 Nov 24;22(1):9-17. doi: 10.1007/BF02010341.
Four groups of weanling rats were fed for 2 weeks on a diet sufficient or insufficient in calcium and/or phosphorus. Each group was divided into four subgroups which were offered distilled water supplemented with 0, 50, 75, or 150 ppm fluoride. High levels of fluoride in drinking water inhibited weight gain. This inhibition was less in rats deficient in phosphorus than when normal-phosphorus diets were offered. At a low level, fluoride was without any effect on bone ash, thickness of femoral cortical bone, and mechanical strength, as measured by maximal load, ultimate stress to breaking, and limit of elasticity. Modulus of elasticity was decreased. At higher levels fluoride tended to decrease most of these parameters, except in rats deprived of both calcium and phosphorus. The effect of fluoride was modified by lack of dietary calcium and/or phosphorus and appeared to be weaker in rats deficient in these nutrients. Lack of dietary calcium and/or phosphorus decreased bone strength more than did fluoride content of water and of bone mineral. Concentration of bone ash and thickness of femoral cortical bone were closely correlated with parameters of mechanical strength.
将四组断乳大鼠用钙和/或磷充足或不足的饲料喂养2周。每组再分为四个亚组，分别给予添加了0、50、75或150 ppm氟化物的蒸馏水。饮用水中高浓度的氟化物会抑制体重增加。与提供正常磷饮食的大鼠相比，磷缺乏的大鼠体重增加受到的抑制较小。低浓度时，氟化物对骨灰、股骨皮质骨厚度以及通过最大负荷、断裂极限应力和弹性极限测量的机械强度没有任何影响。弹性模量降低。在较高浓度时，氟化物往往会使这些参数中的大多数降低，但钙和磷都缺乏的大鼠除外。氟化物的作用会因饮食中钙和/或磷的缺乏而改变，并且在这些营养素缺乏的大鼠中似乎较弱。饮食中钙和/或磷的缺乏比水和骨矿物质中的氟含量更能降低骨强度。骨灰浓度和股骨皮质骨厚度与机械强度参数密切相关。
